Levothyroxine shortage

The medicine shortage reports database includes information about shortages of reportable medicines in Australia, including those arising from the discontinuation of products.. You can use this page to search for all medicines in shortage and find information about management actions, including supply of overseas alternative medicines.. Information in this database is based on details reported ...

Levothyroxine (l ‐thyroxine) sodium is the sodium salt of the levo isomer of the thyroid hormone thyroxin (T4).Synthetic T4 is chemically identical to that produced in the human thyroid gland. Levothyroxine is indicated as a replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology and as an adjunct to surgery and radioiodine therapy in the management of ...kaismama 21 Sep 2014. There are multiple thyroid medications if one has shortage. There is no way you can do it at home. You'd never get the correct dose, nor have the equipment to do it. It is a synthesized medication. There isn't a plant to substitute. About all you can do for a disaster is make sure you keep a few weeks at home.Levothyroxine came to market in the 1960s in the form of sodium L-thyroxine, which was better absorbed than the free-acid thyroxine. Levothyroxine is a drug with a narrow therapeutic index, which is the range of doses at which a medication is effective without unacceptable adverse events. ... In the Netherlands, there was an increasing shortage ...The shortage database has a flag that indicates ones that are Tier 3 drug shortages, which are those that could potentially have the highest impact on Canada's drug supply and health care system. A Tier 3 designation is decided by the Tier Assignment Committee (TAC), composed of federal and provincial/territorial governments, healthcare ...Published: December 22, 2023 10:47am EST. Over the past year there has been a consistent stream of drug supply issues in the UK and internationally. Recent figures show more than 111 products have ...If you are taking 100mcg of Synthroid you may find benefit in taking 2, 50mcg tablets instead of 1, 100mcg tablet. #2. Consider switching from Levothyroxine/Synthroid to Tirosint - Tirosint is a cleaner thyroid medication with only 4 ingredients (3 of which are inactive ingredients).

Useful list. Xxx. 29 Medications That May Cause Adverse Interactions with Thyroid Drugs. The thyroid medication levothyroxine (LEVO-T, LEVOXYL, NOVOTHYROX, SYNTHROID, THYRO-TABS, UNITHROID) is used to treat hypothyroidism, an endocrine disorder resulting from a thyroid homone deficiency that affects about 4.6 percent of the U.S. population.For oral dosage form (solution): For hypothyroidism: Adults and children older than 12 years of age (growth and puberty complete)—Dose is based on body weight and must be determined by your doctor. The dose is usually 1.6 microgram (mcg) per kilogram (kg) of body weight per day but may be less in older adults.Of the 852 brain-dead donors who underwent randomization, 838 were included in the primary analysis: 419 in the levothyroxine group and 419 in the saline group. Hearts were transplanted from 230 ...Doctors have prescribed Synthroid for over 60 years to keep thyroid levels in balance. Learn about the benefits of Synthroid’s precise dosing options. See why it's important to check your pill with every refill. Get brand-name Synthroid for just $25 a month* * With a 90-day prescription. Other pricing available for 30 days ($29.50) and 60 ...Last modified on Mon 15 Jan 2024 12.26 EST. An unprecedented medicines shortage in the NHS is endangering lives, pharmacists have said, as unpublished figures reveal that the number of products in ...This PSNC Briefing provides information on the Serious Shortage Protocol (SSP) for Levothyroxine 12.5mcg tablets issued by the Secretary of State for Health and Social Care on 3 February 2021. SSP10 will enable community pharmacists in England, Wales and Northern Ireland to supply patients with a different strength and quantity of ...Tirosint-SOL (levothyroxine sodium oral solution) has been made available by IBSA Pharma for the treatment of hypothyroidism and pituitary thyrotropin suppression. It is the first liquid formulation of levothyroxine approved by the Food and Drug Administration (FDA). Tirosint-SOL is packaged in monodose ampules in 12 different strengths: 13 mcg ...Once you are on a stable dose of levothyroxine, blood tests may only need to be done once or twice a year. If a switch in levothyroxine products is necessary (for example, due to a drug shortage), the ATA guidelines recommend rechecking thyroid hormone levels once the full effect of the drug is expected.

Levothyroxine (Levoxyl, Synthroid, Tirosint) is a synthetic form of thyroxine (T4), a thyroid hormone. It treats hypothyroidism by bringing your thyroid hormone levels into the desired range. The initial levothyroxine dosage for adults is around 1.6 mcg per kg of body weight. But it may vary based on your age and other health conditions.Characteristics of products in shortage. In the Netherlands, 1844 shortages were reported to pharmacy practice and authorities between 2012 and 2015. The number of shortages increased from 387 in 2012 to 548 in 2015. Over half of the shortages (56.7%) were related to oral products, and three out of ten (30.0%) were related to parenteral products.Serious Shortage Protocol (SSP) for levothyroxine 12.5mcg tablets – corresponding guidance on endorsement, prescription charges, remuneration and reimbursement plus Q&A. SSP for levothyroxine 12.5microgram (mcg) tablets 1) Endorsement The contractor must endorse the prescription form, EPS token or ElectronicSerious Shortage Protocol (SSP) for levothyroxine 12.5mcg tablets – corresponding guidance on endorsement, prescription charges, remuneration and reimbursement plus Q&A. SSP for levothyroxine 12.5microgram (mcg) tablets 1) Endorsement The contractor must endorse the prescription form, EPS token or ElectronicBiden's plan to stem drug shortages involves using the Defense Production Act, a Cold War-era law, to bring drug making back to the U.S.

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Key takeaways: Levothyroxine (Synthroid, Levoxyl, Tirosint) is a medication that treats low thyroid hormone levels. It's one of the most common medications prescribed in the U.S. Common levothyroxine side effects include heat intolerance, a fast heart rate, and diarrhea. Weight loss and hair changes are also possible.Levothyroxine typically causes no side effects when used in the correct dose. If you change brands of the medicine, tell your health care provider, as the dosage may need to change. If you have coronary artery disease or severe hypothyroidism, your health care provider may start treatment with a smaller amount of medicine and then slowly ...LEVOTHYROXINE SODIUM FOR INJECTION: Common or Proper name: Levothyroxine 500mcg / vial: Company Name: AVIR PHARMA INC. Market Status: MARKETED: Active Ingredient(s) ... Reason for shortage: Delay in shipping of the drug. Anticipated start date: 2020-10-30: Actual start date: 2020-10-31: Estimated end date: 2020-11-13: Actual end date: 2020-11-09:Reason for the Shortage. Athenex started marketing levothyroxine sodium in January 2019; Fresenius Kabi has levothyroxine sodium available. Par had levothyroxine sodium on shortage due to increased demand. Piramal Critical Care did not provide a reason for the shortage.Feb 2, 2024 · Big Problems with Thyroid Medications in the Last Few Years. It’s been a tough few years for thyroid patients. Within the last 3-4 years you have had to deal with changes in the formulation of several types of NDT medications, recalls of various types of thyroid medications (including NP thyroid (1) and levothyroxine (2) recalls), and problems with shortages with several types of NDT.

Here's why Levothyroxine is in shortage at a popular pharmacy. What does it mean for prices?Hypothyroidism can be treated with levothyroxine, which is produced from different manufacturers. In 2016, the manufacturer of the levothyroxine brand Thyrax experienced an interruption in production that required many Dutch patients to change their levothyroxine supplier. The current study examined the effect of the shortage of the levothyroxine brand Thyrax in the Netherlands and subsequent ...Last week I made a post about possibly being over medicated due to having hyperthyroidism symptoms such as , insomnia, heart palpitations etc. So I decided to get my labs done. Turns out I'm still very much hypo, more than before my doctor increased my dose. (4.1 at 88mcg and now 5.6 at 100mcg) I take my levo on an empty stomach not always at ...A spokesperson from Walmart tells us Levothyroxine is the only drug at their pharmacies under a shortage and price increase. Despite the notice given to Walmart Pharmacy customers, the FDA says ...Levothyroxine 25 micrograms Tablets. Other formats: To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge: 0800 198 5000 (UK Only) Please be ready to give the following information: Product name Reference number. Levothyroxine 25 Micrograms Tablets 29831/0130.NP Thyroid tablets are composed of levothyroxine and liothyronine, and used to treat hypothyroidism (underactive thyroid). The products subject to recall are packed in 100-count and 7-count ...Levothyroxine (l-thyroxine, l-T4) is a drug of choice for treating congenital and primary hypothyroidism.Although clinically significant interactions between l-T4 and food can alter the safety and efficacy of the treatment, they still seem to be generally underestimated by patients, physicians and pharmacists.This review aimed to investigate the effects of meals, beverages, and dietary ...Published: December 22, 2023 10:47am EST. Over the past year there has been a consistent stream of drug supply issues in the UK and internationally. Recent figures show more than 111 products have ...Mar 13, 2023 · Levothyroxine is a synthetic (man-made) version of thyroxine, or T4, the main hormone that is made and released by your thyroid gland. Levothyroxine is prescribed for people with an underactive thyroid, a condition known as hypothyroidism. Most medications are available in brand-name and generic preparations. The medicine shortage reports database includes information about shortages of reportable medicines in Australia, including those arising from the discontinuation of products. You can use this page to search for all medicines in shortage and find information about management actions, including supply of overseas alternative medicines.

Abstract. Background: The basis for the treatment of hypothyroidism with levothyroxine (LT4) is that humans activate T4 to triiodothyronine (T3). Thus, while normalizing serum thyrotropin (TSH), LT4 doses should also restore the body's reservoir of T3. However, there is evidence that T3 is not fully restored in LT4-treated patients.

A shortage of levothyroxine 12.5 microgram tablets has been identified. Between the 3rd February and 5th March 2021, prescriptions for this item can be fulfilled using levothyroxine 25 microgram tablets to be taken on alternate days. 8. In order to support this change, there is a UK SSP in placeLevothyroxine is a synthetic (man-made) version of thyroxine, or T4, the main hormone that is made and released by your thyroid gland. Levothyroxine is prescribed for people with an underactive thyroid, a condition known as hypothyroidism. Most medications are available in brand-name and generic preparations.Current American Thyroid Association guidelines recommend that women who are treated with levothyroxine for hypothyroidism and planning for pregnancy should have their TSH levels checked before becoming pregnant and to have their levothyroxine dose adjusted to keep TSH below 2.5mIU/L. In general, the levothyroxine dose needs to be increased ...Rybelsus. Rybelsus Online is a convenient and accessible рlatform that allows individuals with type 2 diabetes to easily access and obtаin their prescription medication. With the advent of digital technology аnd online pharmаcies, Rybelsus can now be ordered and delivered to your doorstep with just a few clicks.LEVOTHYROXINE SODIUM. Shortage reports. Brand name Strength Dosage Status Date Created Date Updated Reports LEVOTHYROXINE SODIUM FOR INJECTION: ... Avoided shortage 2021-02-17: 2021-04-07: 134246: SYNTHROID: 137MCG TABLET Resolved 2021-01-14: 2021-01-21: 131541: SYNTHROID: 150MCG TABLET ...Levothyroxine came to market in the 1960s in the form of sodium L-thyroxine, which was better absorbed than the free-acid thyroxine. Levothyroxine is a drug with a narrow therapeutic index, which is the range of doses at which a medication is effective without unacceptable adverse events. ... In the Netherlands, there was an increasing shortage ...Levothyroxine Sodium Tablets, USP are available containing 25 mcg, 50 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200 mcg or 300 mcg of levothyroxine sodium, USP. The 25 mcg tablets are orange, capsule-shaped, scored tablets debossed with L to the left of the score and 4 to the right of the score on one side of ...

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Implications for Patient Care. Famotidine is a histamine type-2 receptor antagonist, or H2 blocker, which reduces gastric acid secretion in response to physiologic and dietary stimuli. Famotidine injection is used for patients with hypersecretory conditions, intractable ulcers, or for patients who cannot receive oral therapy.Elise Amendola/AP. Drug companies often increase prices at the start of the new year, and 2024 seems to be no exception. There have been about 600 price hikes so far in January, according to the ...Background Levothyroxine sodium is widely prescribed to treat primary hypothyroidism. There is consensus that levothyroxine should be taken in the morning on an empty stomach. A pilot study showed that levothyroxine intake at bedtime significantly decreased thyrotropin levels and increased free thyroxine and total triiodothyronine levels.The trend over the last few years is clear. A 2023 pressures survey by Community Pharmacy England found that 92% of pharmacy teams were dealing with medicine supply issues daily, an increase from ...Levothyroxine Sodium Injection: Apr 29, 2024: Feb 16, 2022: Lidocaine 5% Transdermal Patch: Apr 19, 2024: Nov 09, 2022: ... Shortage Resources. Drug shortages statistics, and best practices, guidelines and publications related to drug shortages Learn More. Link the whole card. Related ASHP Sites.One particular symptom that hypothyroid patients often report is brain fog. Interestingly, this symptom is also reported by patients with other chronic medical conditions. This study was done to better understand the symptoms associated with brain fog in patients with hypothyroidism, to find out how often it occurs and to determine what improves the symptoms commonly experienced in patients ...Levothyroxine is a synthetic (man-made) version of thyroxine, or T4, the main hormone that is made and released by your thyroid gland. Levothyroxine is prescribed for people with an underactive thyroid, a condition known as hypothyroidism. Most medications are available in brand-name and generic preparations.Thyroid Drug Shortages Creating Consternation, Confusion. By staff. In September 2020, Acella Pharmaceuticals LLC recalled two lots of NP Throid and RLC Labs Inc. recalled all lots of Nature-Throid and WP Thyroid because testing showed they contained less levothyroxine than the labelled amount. In March of this year, Acella recalled certain ...Adult. Initially 1.6 micrograms/kg once daily, adjusted according to response, round dose to the nearest 25 micrograms, dose to be taken preferably 30–60 minutes before breakfast, caffeine-containing liquids (e.g. coffee, tea), or other medication. Elderly. Initially 25–50 micrograms once daily; adjusted in steps of 25 micrograms every 4 ... ….

Levothyroxine Sodium Injection: Apr 29, 2024: Feb 16, 2022: Lidocaine 5% Transdermal Patch: Apr 19, 2024: Nov 09, 2022: ... Shortage Resources. Drug shortages statistics, and best practices, guidelines and publications related to drug shortages Learn More. Link the whole card. Related ASHP Sites.THYQUIDITY is a liquid oral solution that enables healthcare providers to prescribe the medically appropriate strength of levothyroxine necessary to manage patients’ hypothyroidism1. Because THYQUIDITY dosing depends on a variety of factors, doses must be individualized. Doses >200 mcg/day are seldom required.The shortage database has a flag that indicates ones that are Tier 3 drug shortages, which are those that could potentially have the highest impact on Canada's drug supply and health care system. A Tier 3 designation is decided by the Tier Assignment Committee (TAC), composed of federal and provincial/territorial governments, healthcare ...Familial hyper- or hypo-thyroxine binding globulinemias have been described, with the incidence of TBG deficiency approximating 1 in 9000. 8 USE IN SPECIFIC ...Last modified on Thu 25 Jan 2024 21.31 EST. The EU is to stockpile key medicines that will worsen the record drug shortages in the UK, with experts warning that the country could be left “behind ...Xanax (alprazolam) Zoloft (sertraline) Zyrtec (cetirizine) Levothyroxine alcohol/food interactions. There are 3 alcohol/food interactionswith levothyroxine. Levothyroxine disease interactions. There are 5 disease interactionswith levothyroxine which include: adrenal insufficiency. cardiovascular disease.229. Drug shortages in the US have reached an all-time high, with 323 active and ongoing shortages already tallied this year, according to data collected by the American Society of Health-System ...This includes creating vital domestic shortages to life-saving medicines, leaving an estimated 6 million Iranian patients with limited treatment access for a host of diseases. Sanctions have also crippled Iran's domestic pharmaceutical industry, leading to the disruption of generic medicines production and forcing the country to import ...This PSNC Briefing provides information on the Serious Shortage Protocol (SSP) for Levothyroxine 12.5mcg tablets issued by the Secretary of State for Health and Social …Apr 8, 2024 ... To view profiles and participate in discussions please join or log in . Read more about... Levothyroxine / Liothyronine. Reply Like (0) Levothyroxine shortage, It's usually recommended that you take levothyroxine in the morning. If you follow that advice, take it on an empty stomach. Then avoid food and drink, including coffee, for at least an hour. Some recent research supports taking thyroid medication at bedtime to maximize absorption., Westminster Pharmaceuticals, LLC is voluntarily recalling all lots, within expiry, of Levothyroxine and Liothyronine (Thyroid Tablets, USP) 15 mg, 30 mg, 60 mg, 90 mg, & 120 mg to the wholesale level., Nature-Throid® and WP Thyroid® (thyroid tablets, USP) is composed of liothyronine and levothyroxine, and are used to treat hypothyroidism (underactive thyroid). The products subject to recall ..., For every 2 x levothyroxine 12.5 microgram tablets originally prescribed, the following quantity must be supplied in accordance with this protocol: 1 x 25 microgram …, Drug Shortage Report for SYNTHROID. Last updated on 2017-12-19 History. Report ID: 33596: Drug Identification Number: 02172119: Brand name: SYNTHROID: Common or Proper name: SYNTHROID: ... Reason for shortage: Disruption of the manufacture of the drug. Anticipated start date: 2017-12-21: Actual start date: Estimated end date: Actual end date ..., LEVOTHYROXINE SODIUM. Shortage reports. Brand name Strength Dosage Status Date Created Date Updated Reports LEVOTHYROXINE SODIUM FOR INJECTION: ... Avoided shortage 2021-02-17: 2021-04-07: 134246: SYNTHROID: 75MCG TABLET Resolved 2021-03-02: 2021-04-07: 134941: SYNTHROID: 125MCG TABLET ..., For People Living with Chernobyl’s Effects, A Medication Shortage Threatens Direct Relief has shipped 14 million doses of levothyroxine, a drug used to treat impaired thyroid function, to Ukraine’s Ministry of Health and a Ukrainian NGO in response to increased need., Nov 29, 2023 · Of the 852 brain-dead donors who underwent randomization, 838 were included in the primary analysis: 419 in the levothyroxine group and 419 in the saline group. Hearts were transplanted from 230 ... , Doctors have prescribed Synthroid for over 60 years to keep thyroid levels in balance. Learn about the benefits of Synthroid’s precise dosing options. See why it's important to check your pill with every refill. Get brand-name Synthroid for just $25 a month* * With a 90-day prescription. Other pricing available for 30 days ($29.50) and 60 ..., high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor. Common levothyroxine side effects may include: fever, hot flashes, increased sweating; tiredness; skin rash, hair loss; chest pain, fast or irregular heartbeats, shortness of breath; headache, leg cramps, muscle pain or weakness;, Introduction. Current management guidelines for the management of hypothyroidism focus on the administration of levothyroxine (LT4), with doses titrated to bring thyroid-stimulating hormone (thyrotropin, TSH) within a locally-derived reference range of 'normal' values (1, 2, 3).Spontaneous hypothyroidism is a common condition, affecting approximately 1-2% of adults in iodine-replete ..., LEVOTHYROXINE SODIUM FOR INJECTION: Common or Proper name: Levothyroxine 500mcg: Company Name: AVIR PHARMA INC. Market Status: MARKETED: Active Ingredient(s) LEVOTHYROXINE SODIUM: ... Reason for shortage: Delay in shipping of the drug. Anticipated start date: 2023-03-01: Actual start date: Estimated end date: 2023-03-03: Actual end date: 2023 ..., Shortages of each product (or group of similar products) will have different causes and their rectification will require specific and targeted interventions. Other products for children are also listed on the invitations for expression of interest issued by the WHO Prequalification Programme for HIV/AIDS, including hepatitis B and C, and ..., 4 days ago ... Levothyroxine (Synthroid) · Lexapro ... shortage to end, according to an update from the FDA on April 29. ... However, there is currently no ..., Approximately 23 million Americans take levothyroxine, making it one of the most prescribed drugs in the country. To test for hypothyroidism (underactive thyroid), clinicians measure the levels of ..., Thyroid Drug Shortages Creating Consternation, Confusion. By staff. In September 2020, Acella Pharmaceuticals LLC recalled two lots of NP Throid and RLC Labs Inc. recalled all lots of Nature-Throid and WP Thyroid because testing showed they contained less levothyroxine than the labelled amount. In March of this year, Acella recalled certain ..., Adult. Initially 1.6 micrograms/kg once daily, adjusted according to response, round dose to the nearest 25 micrograms, dose to be taken preferably 30–60 minutes before breakfast, caffeine-containing liquids (e.g. coffee, tea), or other medication. Elderly. Initially 25–50 micrograms once daily; adjusted in steps of 25 micrograms every 4 ..., Coffee interferes with levothyroxine absorption; therefore, hypothyroid patients shouldn't drink it and take levothyroxine at the same time. Instead, coffee should be sipped an hour after taking levothyroxine. Authors of the Pharmaceuticals review found that levothyroxine efficacy decreased when taken with milk, juices, or papaya., Public Meeting for Levothyroxine Sodium Therapeutic Equivalence May 23, 2005, Washington, DC; 2006 Endocrinologic and Metabolic Drugs Advisory Committee; Content current as of: 03/04/2022., In July 2023, the ASHP Drug Shortages Resource Center was updated with the latest quarterly drug shortage statistics from the University of Utah Drug Information Service.1 At the end of the second quarter of 2023, there were 309 active, ongoing drug shortages — the highest number in nearly a decade and close to the all-time high of 320 shortages., Manufacturing Site. Caguas, Puerto Rico, USA. Package Insert. Indications for Levothyroxine sodium tablets include a replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism., Today the Federal Trade Commission (FTC) and the U.S. Department of Health and Human Services (HHS) jointly issued a Request for Information to understand how the practices of two types of pharmaceutical drug middlemen groups—group purchasing organizations (GPOs) and drug wholesalers—may be contributing to generic drug shortages., The shortage of injectable hormone therapy has been occurring off and on in the United States since 2016, but the current shortages seem to have surged in early 2022 and continue today. Each month ..., Published on October 28, 2021. Key takeaways: A drug shortage can happen for many reasons. The specific reason impacts how long a supply problem might last. The FDA …, SYNTHROID: Common or Proper name: LEVOTHYROXINE: Company Name: BGP PHARMA ULC: Market Status: MARKETED: Active Ingredient(s) ... Packaging size: 90BT, 1000BT: ATC code: H03AA: ATC description: THYROID PREPARATIONS: Reason for shortage: Disruption of the manufacture of the drug. Anticipated start date: 2020-10-21: Actual start date: 2020-10-22 ..., Shortages of medicines and vaccines have been reported in countries of all income levels in recent years. Shortages can result from one or multiple causes, including shortages of raw materials, manufacturing capacity problems, industry consolidation, marketing practices, and procurement and supply chain management. Existing approaches to mitigate shortages include advance notice systems ..., However, levothyroxine possesses a prolonged half-life of up to 7 days; therefore, immediate transition to IV levothyroxine may not be clinically necessary in the acute NPO setting. Intravenous levothyroxine is significantly more expensive than equivalent oral doses and may prove to be a financial burden for an institution. By understanding the ..., One of the most popular drugs in the country, levothyroxine – also known as the brand name Synthroid – is in short supply, making prices higher and even leaving some patients without the drug. The shortage is a result of hurricanes Irma and Maria, which hit Puerto Rico nearly four months ago, and … See more, Jun 23, 2021 · Abstract. Purpose: Based on the pharmacokinetic profile of levothyroxine, a 3-day hold guideline for adult patients ordered for intravenous (IV) levothyroxine was implemented at a tertiary academic medical center. The purpose of this study was to evaluate the impact of the implementation of an IV levothyroxine hold guideline. , When and how to treat levothyroxine (LT), T4, poisoning is controversial and the risk of exposure weighted against gastrointestinal decontamination (GID) has been discussed 1.The initial lack of symptoms, coupled with widely varying individual clinical responses, makes it difficult to evaluate the effectiveness of medical treatment in patients with acute LT poisoning 2., In today’s digital age, there is no shortage of options when it comes to purchasing books. From online retailers to local bookstores, the choices can be overwhelming. But fear not...., Levothyroxine is a synthetic thyroid hormone used to treat hypothyroidism, a condition in which the thyroid gland does not produce enough thyroid hormone. Learn about the dosing, indications, interactions, adverse effects, contraindications, and cost of Synthroid, Levoxyl, and other levothyroxine products on Medscape, a trusted source of medical information., Medicine notices Ngā pānui rongoā Details on supply issues, discontinuations, and brand changes. Pharmac funds nearly 1,000 medicines in over 2,000 presentations.